WNK4 Antibody

Cusabio

WNK4 Antibody

20

ImmunoFluorescence, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

WNK4

WNK lysine deficient protein kinase 4

PHA2B, PRKWNK4, serine/threonine-protein kinase WNK4, protein kinase lysine-deficient 4, protein kinase with no lysine 4

Rabbit

IgG

Serine/threonine-protein kinase WNK4

Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+) secretion to maintain integrated homeostasis. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition (By similarity).

Human

-20°C or -80°C

41116161