WRR-483 [1076088-50-0]

MedChem Express

WRR-483 [1076088-50-0]

5

1076088-50-0

Research Use Only

C29H41N7O4S

583.75

WRR-483 is an analog of K11777, an inhibitor of cruzain, used to inhibit the proliferation of Trypanosoma cruzi in cell culture. WRR-483 can eradicate parasitic infection in an acute Chagas disease mouse model. WRR-483 is an irreversible cysteine protease inhibitor that shows pH-dependent high affinity and potent trypanocidal activity against cruzain and T. cruzi infection, and is expected to inhibit Chagas disease.

O=C(N1CCN(CC1)C)N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC2=CC=CC=C2)/C=C/S(=O)(C3=CC=CC=C3)=O)=O

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