WRX606 [899937-47-4]

TargetMol Chemicals

WRX606 [899937-47-4]

9

Research Use Only

C28H25ClN4O6

548.97

WRX606 is an inhibitor of the mammalian target of rapamycin complex 1 (mTORC1). In MCF-7 cells, it inhibits the phosphorylation of mTORC1 substrate S6 kinase 1 (p-S6K1) with an IC50 value of 10 nM, and the phosphorylation of eukaryotic translation initiation factor 4E binding protein (p-4E-BP1) with an IC50 of 0.27 microM. Additionally, WRX606 exhibits cytotoxicity in HepG2 cells with an IC50 of 17 nM and has demonstrated antitumor efficacy in mouse models.

O=C(NC=1C=CC=C(Cl)C1)CN2C(=O)N(C(=O)C=3C=CC=CC32)CCCC(=O)NCC4=CC=C5OCOC5=C4

-20°C

12352200