WS3 --- beta Cell Proliferation Inducer [1421227-52-2] [1421227-52-2]

Bioss

WS3 --- beta Cell Proliferation Inducer [1421227-52-2] [1421227-52-2]

16

1421227-52-2

Research Use Only

Unconjugated

98 - 98.0

C28 H30 F3 N7 O3

569.58

WS3 is a highly potent and selective small molecule that promotes pancreatic beta cell and RPE cells expansion, identified by a high-throughput, cell-based screening. It can induce proliferation of mouse R7T1 beta cells with an EC50 ~0.074 microM, and expansion of primary rat and human beta cells in dissociated and intact islet format with similar EC50. WS3 can also reversibly proliferate primary RPE cells isolated from fetal and adult human donors. Following withdrawal of WS3, RPE cells differentiate into a functional monolayer, as exhibited by their expression of mature RPE genes and phagocytosis of photoreceptor outer segments. Furthermore, chemically expanded RPE cells preserve vision when transplanted into dystrophic Royal College of Surgeons (RCS) rats, a well-established model of retinal degeneration.

CN1CCN(CC2C=CC(=CC=2C(F)(F)F)NC(=O)NC2C=CC(=CC=2)OC2=CC(NC(=O)C3CC3)=NC=N2)CC1

-20°C

41106200