WS6 --- beta Cell Proliferation Inducer

Bioss Antibodies

WS6 --- beta Cell Proliferation Inducer [1421227-53-3]

16

Research Use Only

WS6 is a highly potent and selective small molecule that promotes pancreatic beta cell proliferation in rodent and human primary islets, identified by a high-throughput, cell-based screening using rodent pancreatic beta cells. It can induce proliferation of mouse R7T1 cells with an EC50 ~0.28 microM, and induce up to 4% of rat beta cells and 3% of human beta cells to proliferate, with a similar EC50 of 0.4 microM. WS6 induces proliferation of primary rat and human beta cells in intact islet format at 0.2-1.0 microM concentration. In the RIP-DTA mouse model of beta cell ablation, WS6 demonstrated excellent in vivo effect on normalizing blood glucose and inducing concomitant increases in beta cell proliferation and beta cell number. Affinity pulldown and kinase profiling studies implicate Erb3 binding protein-1 and the IkappaB kinase pathway in the mechanism of action of WS6.

-20°C

41116155