WWL123 analogue-1 [1338575-41-9]

MedChem Express

WWL123 analogue-1 [1338575-41-9]

10

1338575-41-9

Research Use Only

98.04

C28H24N2O3

436.50

WWL123 analogue-1 is an analogue of WWL123. WWL123 is a potent and selective ABHD6 inhibitor with an IC50 of 430 nM[1][2]. WWL123 crosses the blood-brain-barrier and inhibits ABHD6 in brain parenchyma. ABHD6 blockade by WWL123 exerts an antiepileptic effect in Pentylenetetrazole (PTZ)-induced epileptiform seizures and spontaneous seizures in R6/2 mice[3].

O=C(C1=CC=C(C2=CC=CC(OC(N(CC3=CC=CC(C4=CC=CC=C4)=C3)C)=O)=C2)C=C1)N

-20°C,2°C to 8°C

12352200