Xanthine oxidase-IN-17

MedChem Express

Xanthine oxidase-IN-17

999

Research Use Only

C17H16O4

284.31

Xanthine oxidase-IN-17 is a potent xanthine oxidase (XOD) inhibitor with an IC50 of 298 nM and a Ki of 167 nM. Xanthine oxidase-IN-17 decreases the formation of O2- radical by inhibiting the catalytic activity of XOD to diminish the production of uric acid. Xanthine oxidase-IN-17 shows no cytotoxicity in AML-12 hepatocytes, while suppressing uric acid production. Xanthine oxidase-IN-17 can be used for the studies of hyperuricemia and subsequently to gout[1].

COC1=CC=C(C(/C=C/C2=CC=C(O)C=C2)=O)C(OC)=C1

12352200