XAV939---Wnt Antagonist

Bioss

XAV939---Wnt Antagonist [284028-89-3]

16

Research Use Only

98.0

XAV939 is a potent and selective Wnt pathway antagonist. It functions to stabilize Axin by inhibiting the poly-ADP-ribosylating enzymes tankyrase 1 and tankyrase 2 with IC50 of 11 nM and 4 nM, respectively. It has been used to study Wnt-dependent cancers. In addition, XAV939 was shown to stabilize Axin2 level in oligodendrocyte precursor cells in the spinal cord and accelerated their differentiation and myelination after hypoxic and demyelinating injury. It can also robustly induce cardiomyocyte differentiation from mouse and human ESCs/iPSCs.

-20°C

51202000