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XEN445 [1515856-92-4]

Research Use Only
HY-12246
MedChem Express
CAS Number1515856-92-4
Product group Chemicals
Estimated Purity99.85
Molecular Weight366.33
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Overview

  • Supplier
    MedChem Express
  • Product Name
    XEN445 [1515856-92-4]
  • Delivery Days Customer
    10
  • CAS Number
    1515856-92-4
  • Certification
    Research Use Only
  • Estimated Purity
    99.85
  • Molecular Formula
    C18H17F3N2O3
  • Molecular Weight
    366.33
  • Scientific Description
    XEN445 is a potent and selective EL inhibitor(IC50=0.237 uM), that showed good ADME and PK properties, and demonstrated in vivo efficacy in raising plasma HDLc concentrations in mice. IC50 value: 0.237 uM [1] Target: Endothelial lipase inhibitor XEN445 can be readily prepared in good yield from commercial available chemicals, which was selected for further evaluation of this series of EL inhibitors. After a 30 min preincubation of EL-expressing HEK cells with XEN445, the IC50 value for XEN445 of 0.25 lM was obtained. This value was very similar to that determined in the cell-free assay. Wild-type mice were orally dosed with XEN445 at 30 mg/kg b.i.d. for 3 days and blood was taken on the morning of day 4, 16 h post final dose. At termination, the average plasma levels of XEN445 was 9.9 lM and the drug caused an 18% and 16% increase in total plasma cholesterol and HDLc, respectively.
  • SMILES
    O=C(O)C1=CC(C(F)(F)F)=CC=C1N2C[C@@H](OCC3=NC=CC=C3)CC2
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200