XIAP-CASP7 PPI-IN-1

MedChem Express

XIAP-CASP7 PPI-IN-1

999

Research Use Only

C25H21N3O3

411.45

Xiap-casp7 PPI-IN-1 is a reversible XIAP: CASP7 inhibitor with specifically disrupting the interaction between XIAP and CASP7. XIAP-CASP7 PPI-IN-1 selectively induce MCF-7 and other caspase-3 down-regulation (CASP3/DR) triple-negative breast cancer cell apoptosis. XIAP-CASP7 PPI-IN-1 overcomes chemoresistance via down-regulating beta-catenin and its associated ABC transporters in Paclitaxel (HY-B0015)-resistant MCF-7 cells. XIAP-CASP7 PPI-IN-1 can be used for the study of breast cancer[1].

COC1=CC2=C(C3=C(N(N=C3C)C4=CC=CC=C4)N=C2C5=CC=C(O)C=C5)C=C1OC

12352200