XK469 [157435-10-4]

TargetMol Chemicals

XK469 [157435-10-4]

72

Research Use Only

XK469

C17H13ClN2O4

344.75

XK489 is a synthetic quinoxaline phenoxypropionic acid derivative with proapoptotic and antiproliferative activities. R(+)XK469 selectively inhibits topoisomerase II-beta, blocks activation of MEK/MAPK signaling kinases, stimulates caspases, and upregulates p53-dependent proteins, including cyclins A and B1, thereby arresting cancer cells in the G2/M phase of the cell cycle. Both R(+) and S(-) isomers of this agent are cytotoxic, although the R-isomer is more potent.

3 years

O(C1=NC2=C(N=C1)C=CC(Cl)=C2)C3=CC=C(OC(C(O)=O)C)C=C3

-20°C

12352200