XOR/URAT1-IN-1

Biorbyt

XOR/URAT1-IN-1

10

Research Use Only

98.00%

C18H13ClN2O3

340.76

Compound II15, known as XOR/URAT1-IN-1, serves as a dual inhibitor targeting xanthine oxidoreductase (XOR) and uric acid transporter 1 (URAT1), exhibiting IC50 values of 6 nM and 12.9 microM, respectively. This compound effectively reduces uric acid levels in a mouse model of acute hyperuricemia induced by potassium oxonate and hypoxanthine.

O=C(O)C=1C=CC(=CC1O)C2=CN=CC(=C2)NC=3C=CC=C(Cl)C3

-20°C

12352200