XP5

MedChem Express

XP5

10

Research Use Only

C19H25N3O5S

407.48

XP5 is a potent, orally active HDAC6 inhibitor with an IC50 of 31 nM. XP5 displays high antiproliferative activity against various cancer cell lines including the HDACi-resistant YCC3/7 gastric cancer cells (IC50=0.16-2.31 microM). XP5 enhances antitumor immunity when combined with a PD-L1 inhibitor in melanoma[1].

COC1=CC=C(C(OC)=C1)C2=NC=C(S2)C(NCCCCCCC(NO)=O)=O

12352200