XPG antibody

GeneTex

XPG antibody [8H7]

9

Epitope: 8H7 binds between human XPG residues Ser 947 and Ala 1165.

Suggested working dilutions: Western blot: 1:625-1:1250, immunoprecipitation: 2 microg/mg protein lysate.

ImmunoPrecipitation, Western Blot

Research Use Only

Monoclonal

1 mg/ml

Unconjugated

Liquid

ERCC5

ERCC excision repair 5, endonuclease

COFS3; DNA excision repair protein ERCC-5; DNA repair protein complementing XP-G cells; ERCC5-201; ERCM2; excision repair cross-complementation group 5; excision repair cross-complementing rodent repair deficiency, complementation group 5; UVDR; xeroderma pigmentosum, complementation group G; XPG; XPGC; XPG-complementing protein

Mouse

IgG2a

DNA repair protein complementing XP-G cells

This gene encodes a single-strand specific DNA endonuclease that makes the 3 incision in DNA excision repair following UV-induced damage. The protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure. Some patients also develop Cockayne syndrome, which is characterized by severe growth defects, cognitive disability, and cachexia. Read-through transcription exists between this gene and the neighboring upstream BIVM (basic, immunoglobulin-like variable motif containing) gene. [provided by RefSeq, Feb 2011]

Human

-20°C or -80°C,2°C to 8°C

12352203