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Y-27632 (hydrochloride hydrate)

HY-10071A
MedChem Express
CAS Number331752-47-7
DownloadMSDS
Product group Chemicals
Molecular Weight338.27
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Y-27632 (hydrochloride hydrate) [331752-47-7]
  • Delivery Days Customer
    5
  • CAS Number
    331752-47-7
  • Certification
    Research Use Only
  • Molecular Formula
    C14H25Cl2N3O2
  • Molecular Weight
    338.27
  • Scientific Description
    Y-27632 hydrochloride hydrate is an orally active, ATP-competitive inhibitor of ROCK-I and ROCK-II , with K i s of 220 and 300 nM, respectively. Y-27632 hydrochloride hydrate attenuates Doxorubicin-induced apoptosis of human cardiac stem cells. Y-27632 hydrochloride hydrate also suppresses dissociation-induced apoptosis of murine prostate stem/progenitor cells. Y-27632 hydrochloride hydrate primes human induced pluripotent stem cells (hIPSCs) to selectively differentiate towards mesendodermal lineage via epithelial-mesenchymal transition-like modulation [1] [2] [3] [4] [5] [6] [7] .
  • SMILES
    O=C([C@H]1CC[C@](CC1)([H])[C@H](N)C)NC2=CC=NC=C2.Cl.O.Cl
  • UNSPSC
    12352200