Y-27632 (hydrochloride hydrate)
HY-10071A
Overview
- SupplierMedChem Express
- Product NameY-27632 (hydrochloride hydrate) [331752-47-7]
- Delivery Days Customer5
- CAS Number331752-47-7
- Molecular FormulaC14H25Cl2N3O2
- Molecular Weight338.27
- Scientific DescriptionY-27632 hydrochloride hydrate is an orally active, ATP-competitive inhibitor of ROCK-I and ROCK-II , with K i s of 220 and 300 nM, respectively. Y-27632 hydrochloride hydrate attenuates Doxorubicin-induced apoptosis of human cardiac stem cells. Y-27632 hydrochloride hydrate also suppresses dissociation-induced apoptosis of murine prostate stem/progenitor cells. Y-27632 hydrochloride hydrate primes human induced pluripotent stem cells (hIPSCs) to selectively differentiate towards mesendodermal lineage via epithelial-mesenchymal transition-like modulation [1] [2] [3] [4] [5] [6] [7] .
- SMILESO=C([C@H]1CC[C@](CC1)([H])[C@H](N)C)NC2=CC=NC=C2.Cl.O.Cl
- UNSPSC12352200