YAP/TAZ-TEAD-IN-2

MedChem Express

YAP/TAZ-TEAD-IN-2

5

Research Use Only

C19H20N2O3S

356.44

YAP/TAZ-TEAD-IN-2 (Compound 51) is a YAP/TAZ-TEAD inhibitor that inhibits the interaction between YAP/TAZ and TEAD. YAP/TAZ-TEAD-IN-2 suppresses the transcriptional activity of TEAD, with an IC50 of 1.2 nM. YAP/TAZ-TEAD-IN-2 inhibits YAP/TAZ-TEAD target genes expression (Cyr61, CTGF, AXL and Survivin) and breast cancer cell proliferation[1].

O=S(NCCN(C=C1)C(C1=C2)=CC=C2OCC3=CC=CC=C3)(C=C)=O

12352200