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ProductsBack/YH239-EE [1364488-67-4]

YH239-EE [1364488-67-4]

Research Use Only
HY-12287
MedChem Express
CAS Number1364488-67-4
DownloadMSDS
Product group Chemicals
Estimated Purity98.28
Molecular Weight504.41
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Overview

  • Supplier
    MedChem Express
  • Product Name
    YH239-EE [1364488-67-4]
  • Delivery Days Customer
    10
  • CAS Number
    1364488-67-4
  • Certification
    Research Use Only
  • Estimated Purity
    98.28
  • Molecular Formula
    C25H27Cl2N3O4
  • Molecular Weight
    504.41
  • Scientific Description
    YH239-EE, ethyl ester of the free carboxylic acid compound YH239, is a potent p53-MDM2 antagonizing and apoptosis-inducing agent. IC50 value: Target: MDM2/p53 YH239-EE inhibits the growth of OCI-AML-3 cells with wild type p53 by inhibiting the p53-MDM2 interaction. YH239-EE induces cell cycle arrest and causes potent cell apoptosis via activation of p53 and downstream targets in four AML cells (OCI-AML-3 and MOLM-13 with wt p53, NB4 with p53 mutation, and HL60 with p53 deletion).
  • SMILES
    O=C(C(N1)=C(C(N(CC2=CC=C(Cl)C=C2)C=O)C(NC(C)(C)C)=O)C3=C1C=C(Cl)C=C3)OCC
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200