YK 3-237

AbMole BioScience

YK 3-237

9

1215281-19-8

Chemical

Research Use Only

C19H21BO7

372.18

YK 3-237 is a boronic acid chalcone analog of combretastatin a4 (CA-4) and a SIRT1 activator that targets mutant p53. YK 3-237 can reduce the acetylation of mutant p53 protein by activating the SIRT1 enzyme, resulting in a significant decrease in the level of mutant p53 protein. YK-3-237 showed antiproliferative activity against tumor cells containing mutant p53 protein.

COC1=C(OC)C(=CC(=C1)C(=O)/C=C/C2=CC=C(OC)C(=C2)B(O)O)OC

12352200