YKL-1-116 [1957202-71-9]

MedChem Express

YKL-1-116 [1957202-71-9]

14

1957202-71-9

Research Use Only

98.67

C34H38N8O3

606.72

YKL-1-116 is a selective and covalent inhibitor of Cdk7. YKL-1-116 does not target Cdk9, Cdk12, or Cdk13. YKL-1-116 is more potent than THZ1 (HY-80013) toward both Cdk7WT and Cdk7as, although Cdk7as is relatively resistant to this compound as well[1].

CC(C)(N(C1)C(N[C@@H](C2=CC=CC=C2)CN(C)C)=O)C3=C1C(NC4=CC(NC(C5=CC=C(C=C5)NC(C=C)=O)=O)=CC=C4)=NN3

-20°C,2°C to 8°C

12352200