YL93

MedChem Express

YL93 [2771313-42-7]

10

Research Use Only

C37H38Cl2F2N4O4

711.62

YL93 is a dual inhibitors of MDM2/4 with Ki values of 0.64 microM and 1.1 nM for MDM4 and MDM2, respectively. YL93 induces cell-cycle arrest and apoptosis. YL93 shows p53-dependent cell growth inhibition[1].

FC(C(Cl)=CC=C1)=C1[C@@H]([C@@H](N[C@H]2CC(C)(C)C)C(NC3=CC=C(C=C3OC)C(O)=O)=O)[C@]2(C4=CC=C(Cl)C=C4F)CNCC5=CC=NC=C5

12131703