YLT192 [1246566-47-1]

MedChem Express

YLT192 [1246566-47-1]

9

1246566-47-1

Research Use Only

C21H19N3O4

377.39

YLT192 is an orally active and highly bioavailable VEGFR2 inhibitor with potent anti-angiogenic activity and anti-tumor efficacy. YLT192 significantly inhibited the kinase activity of VEGFR2 and inhibited the proliferation, migration, invasion and tube formation of human umbilical cord vascular endothelial cells. YLT192 also inhibited VEGF-induced VEGFR2 phosphorylation and its downstream signaling regulators. YLT192 also showed the ability to inhibit angiogenesis in vivo in zebrafish embryo models and alginate-coated tumor cell experiments. YLT192 can directly inhibit the proliferation of cancer cells and induce their apoptosis[1].

O=C(NC)C1=NC=CC(OC2=CC=C(C=C2)NC(C3=CC=CC(OC)=C3)=O)=C1

12352200