YM-201636 [371942-69-7] [371942-69-7]

Bioss

YM-201636 [371942-69-7] [371942-69-7]

16

371942-69-7

Research Use Only

Unconjugated

98 - 98.0

C25 H21 N7 O3

467.48

YM-201636 is an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3, 5)P2 synthesis, and can also halt glucose entry by insulin in adipocytes. YM-201636 almost completely inhibited basal and insulin-activated 2-deoxyglucose uptake at doses as low as 160 nM, with IC(50)=54+/-4 nM for the net insulin response. Insulin-induced GLUT4 translocation was partially inhibited at substantially higher doses, comparable to those required for inhibition of insulin-induced phosphorylation of Akt/PKB. In addition to PIKfyve, YM-201636 also completely inhibited insulin-dependent activation of class IA PI 3-kinase.

NC1C=CC(=CN=1)C(=O)NC1C=C(C=CC=1)C1=NC2=C(OC3N=CC=CC=32)C(=N1)N1CCOCC1

-20°C

12161509