YM-202074 [299900-83-7]
HY-117132
CAS Number299900-83-7
Product group Chemicals
Molecular Weight414.56
Overview
- SupplierMedChem Express
- Product NameYM-202074 [299900-83-7]
- Delivery Days Customer999
- CAS Number299900-83-7
- CertificationResearch Use Only
- Molecular FormulaC22H30N4O2S
- Molecular Weight414.56
- Scientific DescriptionYM-202074 is a selective, allosteric metabotropic glutamate receptor type 1 (mGluR1) antagonist with high affinity. YM-202074 binds to the allosteric site of rat mGluR1 with a Ki of 4.8 nM. YM-202074 fumarate also inhibits mGluR1-mediated inositol phosphate production in rat cerebellar granule cells with an IC50 of 8.6 nM. YM-202074 has potent neuroprotective effects in transient MCA (tMCA) occlusion rat models[1].
- SMILESO=C(N(C1CCCCC1)C)C2=CN3C4=C(C=CC(CN(CCOC)C)=C4)N=C3S2
- UNSPSC12352200