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ProductsBack/YM-244769 (hydrochloride) [837424-39-2]

YM-244769 (hydrochloride) [837424-39-2]

HY-107659

CAS Number837424-39-2

Product group Chemicals

Estimated Purity99.02

Molecular Weight479.93

Overview

Supplier
MedChem Express
Product Name
YM-244769 (hydrochloride) [837424-39-2]
Delivery Days Customer
10
CAS Number
837424-39-2
Certification
Research Use Only
Estimated Purity
99.02
Molecular Formula
C26H23ClFN3O3
Molecular Weight
479.93
Scientific Description
YM-244769 hydrochloride is a potent, selective and orally active Na+/Ca2+ exchanger (NCX) inhibitor. YM-244769 hydrochloride preferentially inhibits NCX3 and suppresses the unidirectional outward NCX current (Ca2+ entry mode), with IC50s of 18 nM and 50 nM, respectively. YM-244769 hydrochloride efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. YM-244769 hydrochloride can also increase urine volume and urinary excretion of electrolytes in mice[1][2][3].
SMILES
O=C(C1=CN=C(C=C1)OC2=CC=C(C=C2)OCC3=CC(F)=CC=C3)NCC4=CC(N)=CC=C4.[H]Cl
Storage Instruction
-20°C,2°C to 8°C
UNSPSC
12352200

MSDS

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