YM-53601

MedChem Express

YM-53601 [182959-33-7]

10

182959-33-7

99.26

C21H22ClFN2O

372.86

YM-53601, a squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in vivo [1] . YM-53601 inhibits squalene synthase derived from human hepatoma cells with an IC 50 of 79 nM. Lipid-lowering agent [2] . YM-53601 is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 ( FDFT1 ) enzyme activity and abrogates HCV propagation [3] .

F/C(COC1=CC(NC2=C3C=CC=C2)=C3C=C1)=C4CN5CCC/4CC5.[H]Cl

2°C to 8°C

12352200