YNT-185 (dihydrochloride) [1804978-82-2]

MedChem Express

YNT-185 (dihydrochloride) [1804978-82-2]

10

1804978-82-2

Research Use Only

99.78

C33H39Cl2N5O5S

688.66

YNT-185 dihydrochloride is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC50s of 0.028 and 2.75 microM for OX2R and OX1R, respectively. YNT-185 dihydrochloride ameliorates narcolepsy-cataplexy symptoms in mouse models[1][2].

O=[S](NC1=CC(NCCNC(C(C=CC=C2)=C2N(C)C)=O)=CC=C1)(C(C=C(C3=CC(C(N(C)C)=O)=CC=C3)C=C4)=C4OC)=O.Cl.Cl

2°C to 8°C

12131703