YZ129 [1643120-60-8]

MedChem Express

YZ129 [1643120-60-8]

10

1643120-60-8

Research Use Only

99.85

C19H12N2O2

300.31

YZ129 is an inhibitor of the HSP90-calcineurin-NFAT pathway against glioblastoma, directly binding to heat shock protein 90 (HSP90) with an IC50 of 820 nM on NFAT nuclear translocation. YZ129-induced GBM cell-cycle arrest at the G2/M phase promotes apoptosis and inhibited tumor cell proliferation and migration[1].

O=C(C1=CC=CC=C1C(NC2=CC=C(C=NC=C3)C3=C2)=C4)C4=O

-20°C,2°C to 8°C

12352200