(Z)-NMac1 [1667730-59-7]

MedChem Express

(Z)-NMac1 [1667730-59-7]

5

Research Use Only

C24H28O4

380.48

(Z)-NMac1 is an Nm23-H1 activator found in Zingiber cassumunar Roxb. (Z)-NMac1 has dual anti-metastatic and anti-proliferative biological activities. (Z)-NMac1 selectively inhibits cancer cell proliferation under glucose starvation conditions by inhibiting mitochondrial complex I activity, leading to ATP depletion and mitochondrial dysfunction. (Z)-NMac1 can be used to study tumors with high oxidative phosphorylation, especially in the glucose-restricted tumor microenvironment[1].

COC(C=C1/C=C\C2C(C3=CC(OC)=C(C=C3)OC)C=CCC2)=C(C=C1)OC

12352200