(Z)-RG-13022 [149286-90-8]

MedChem Express

(Z)-RG-13022 [149286-90-8]

5

149286-90-8

Research Use Only

C16H14N2O2

266.29

(Z)-RG-13022 is a tyrosine kinase (TK) inhibitor, which inhibits preferentially the TK activity of the EGF receptor and inhibits EGF-stimulated growth of cultured cells. (Z)-RG-13022 exerts an IC50 of 11 microM for DNA synthesis in the HN5 cells, which is 3 times more potent than (E)-RG-13022 (IC50=38 microM). (Z)-RG-13022 can be used for research of breast cancer cells[1][2].

N#C/C(C1=CN=CC=C1)=C\C2=CC(OC)=C(C=C2)OC

12352200