Z62954982 [1090893-12-1]

MedChem Express

Z62954982 [1090893-12-1]

9

1090893-12-1

Research Use Only

99.38

C20H21N3O5S

415.46

Z62954982 (ZINC08010136) is a potent, selective and cell-permeable Rac1 (IC50=12 microM) inhibitor that is 4 times more effective than NSC23766 (HY-15723A) (IC50=50 microM). Z62954982 disrupts the Rac1/Tiam1 complex and decreases cytoplasmic levels of active Rac1 (GTP-bound Rac1), without affecting the activity of other Rho GTPases (such as Cdc42 or RhoA)[1][2].

O=C(NC1=CC=C(C)C(S(=O)(N)=O)=C1)C2=CC=CC(OCC3=C(C)ON=C3C)=C2

-20°C

12352200