Zamicastat [1080028-80-3]

MedChem Express

Zamicastat [1080028-80-3]

5

1080028-80-3

Research Use Only

99.95

C21H21F2N3OS

401.47

Zamicastat (BIA 5-1058) is a dopamine beta-hydroxylase (DBH) inhibitor and can cross the blood-brain barrier (BBB) to cause central as well as peripheral effects. Zamicastat is also a concentration-dependent dual P-gp and BCRP inhibitor with IC50 values of 73.8 microM and 17.0 microM, respectively[1]. Zamicastat reduces high blood pressure[2].

S=C1N([C@@H]2CC3=CC(F)=CC(F)=C3OC2)C(CCNCC4=CC=CC=C4)=CN1

-20°C,2°C to 8°C

12352200