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ZHX2 antibody [C1C3]

GTX112232
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
Product group Antibodies
ReactivityHuman, Mouse
TargetZHX2
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Overview

  • Supplier
    GeneTex
  • Product Name
    ZHX2 antibody [C1C3]
  • Delivery Days Customer
    9
  • Antibody Specificity
    Knockdown/Knockout validation was supported by references (PMID:36037364)
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.7 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID22882
  • Target name
    ZHX2
  • Target description
    zinc fingers and homeoboxes 2
  • Target synonyms
    AFP regulator 1; AFR1; alpha-fetoprotein regulator 1; RAF; regulator of AFP; transcription factor ZHX2; zinc finger and homeodomain protein 2; zinc fingers and homeoboxes protein 2
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ9Y6X8
  • Protein Name
    Zinc fingers and homeoboxes protein 2
  • Scientific Description
    The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family. [provided by RefSeq]
  • Reactivity
    Human, Mouse
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Characterization of circSEC11A as a novel regulator of Iodine-125 radioactive seed-induced anticancer effects in hepatocellular carcinoma via targeting ZHX2/GADD34 axis.
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  • ZHX2 deficiency enriches hybrid MET cells through regulating E-cadherin expression.
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  • USP13 promotes deubiquitination of ZHX2 and tumorigenesis in kidney cancer.
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  • PROBER identifies proteins associated with programmable sequence-specific DNA in living cells.
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  • Novel VHL substrate targets SFMBT1 and ZHX2 may be important prognostic predictors in patients with ccRCC. Chen Y et al., 2021 May, Oncol Lett
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  • ZHX2 mediates proteasome inhibitor resistance via regulating nuclear translocation of NF-kappaB in multiple myeloma. Jiang J et al., 2020 Oct, Cancer Med
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  • Proline Hydroxylation Primes Protein Kinases for Autophosphorylation and Activation. Lee SB et al., 2020 Aug 6, Mol Cell
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  • ZHX2 drives cell growth and migration via activating MEK/ERK signal and induces Sunitinib resistance by regulating the autophagy in clear cell Renal Cell Carcinoma. Zhu L et al., 2020 May 7, Cell Death Dis
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  • Resources for the Comprehensive Discovery of Functional RNA Elements. Sundararaman B et al., 2016 Mar 17, Mol Cell
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