ZK53

MedChem Express

ZK53 [3031789-26-8]

14

Research Use Only

98.94

C19H20BrF2N3O

424.28

ZK53 is a selective activator of mitochondrial caseinolytic protease P (HsClpP) (EC50: 1.37 microM for alpha-casein hydrolysis by HsClpP). ZK53 is is inactive toward bacterial ClpP proteins. ZK53 induces apoptosis in H1703, H520 and SK-MES-1 cells. ZK53 induces dysregulation of mitochondrial functions in lung squamous cell carcinoma (LUSC) cells. ZK53 inhibits tumor growth in H1703 xenograft mouse model[1].

FC1=CC(F)=CC(CN2CCN(C(NCC3=CC=C(Br)C=C3)=O)CC2)=C1

-20°C,2°C to 8°C

12131703