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ProductsBack/ZLDI-8 [667880-38-8]

ZLDI-8 [667880-38-8]

HY-123931
MedChem Express
CAS Number667880-38-8
DownloadMSDS
Product group Chemicals
Estimated Purity98.47
Molecular Weight433.52
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Overview

  • Supplier
    MedChem Express
  • Product Name
    ZLDI-8 [667880-38-8]
  • Delivery Days Customer
    5
  • CAS Number
    667880-38-8
  • Certification
    Research Use Only
  • Estimated Purity
    98.47
  • Molecular Formula
    C24H23N3O3S
  • Molecular Weight
    433.52
  • Scientific Description
    ZLDI-8 is a Notch activating/cleaving enzyme ADAM-17 inhibitor and inhibits the cleavage of Notch protein. ZLDI-8 decreases the expression of pro-survival/anti-apoptosis and epithelial-mesenchymal transition (EMT) related proteins. ZLDI-8 is also a competitive and irreversible tyrosine phosphatase (Lyp) inhibitor with an IC50 of 31.6 microM and a Ki of 26.22 microM. ZLDI-8 inhibits the growth of MHCC97-H cells with an IC50 of 5.32 microM[1][2].
  • SMILES
    O=C(/C(C(N1)=O)=C/C2=C(C)N(CCOC3=CC=C(C)C=C3C)C4=C2C=CC=C4)NC1=S
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12131703

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