Immunofluorescent analysis of Hela cells using CSB-PA026578LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

ZNF207 Antibody

CSB-PA026578LA01HU

ApplicationsImmunoFluorescence, ELISA

Product group Antibodies

ReactivityHuman

TargetZNF207

Overview

Supplier
Cusabio
Product Name
ZNF207 Antibody
Delivery Days Customer
20
Applications
ImmunoFluorescence, ELISA
Certification
Research Use Only
Clonality
Polyclonal
Conjugate
Unconjugated
Gene ID7756
Target name
ZNF207
Target description
zinc finger protein 207
Target synonyms
BuGZ, hBuGZ, BUB3-interacting and GLEBS motif-containing protein ZNF207
Host
Rabbit
Isotype
IgG
Protein IDO43670
Protein Name
BUB3-interacting and GLEBS motif-containing protein ZNF207
Scientific Description
Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly (PubMed:24462186, PubMed:24462187, PubMed:26388440). ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440). Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 (PubMed:24462186, PubMed:24462187). Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187).
Reactivity
Human
Storage Instruction
-20°C or -80°C
UNSPSC
41116161

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ZNF207 Antibody

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