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ZNF598 antibody [N1N3]

GTX119245
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetZNF598
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Overview

  • Supplier
    GeneTex
  • Product Name
    ZNF598 antibody [N1N3]
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.29 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID90850
  • Target name
    ZNF598
  • Target description
    zinc finger protein 598, E3 ubiquitin ligase
  • Target synonyms
    HEL2, E3 ubiquitin-protein ligase ZNF598
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ86UK7
  • Protein Name
    E3 ubiquitin-protein ligase ZNF598
  • Reactivity
    Human, Mouse
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • De S, Mühlemann O. A comprehensive coverage insurance for cells: revealing links between ribosome collisions, stress responses and mRNA surveillance. RNA Biol. 2022,19(1):609-621. doi: 10.1080/15476286.2022.2065116
    Read this paper
  • Rimal S, Li Y, Vartak R, et al. Inefficient quality control of ribosome stalling during APP synthesis generates CAT-tailed species that precipitate hallmarks of Alzheimer's disease. Acta Neuropathol Commun. 2021,9(1):169. doi: 10.1186/s40478-021-01268-6
    Read this paper
  • Wan L, Juszkiewicz S, Blears D, et al. Translation stress and collided ribosomes are co-activators of cGAS. Mol Cell. 2021,81(13):2808-2822.e10. doi: 10.1016/j.molcel.2021.05.018
    Read this paper
  • Shin EM, Huynh VT, Neja SA, et al. GREB1: An evolutionarily conserved protein with a glycosyltransferase domain links ERα glycosylation and stability to cancer. Sci Adv. 2021,7(12). doi: 10.1126/sciadv.abe2470
    Read this paper
  • Hildebrandt A, Brüggemann M, Rücklé C, et al. The RNA-binding ubiquitin ligase MKRN1 functions in ribosome-associated quality control of poly(A) translation. Genome Biol. 2019,20(1):216. doi: 10.1186/s13059-019-1814-0
    Read this paper
  • Wang G, Kouwaki T, Okamoto M, et al. Attenuation of the Innate Immune Response against Viral Infection Due to ZNF598-Promoted Binding of FAT10 to RIG-I. Cell Rep. 2019,28(8):1961-1970.e4. doi: 10.1016/j.celrep.2019.07.081
    Read this paper
  • Garzia A, Jafarnejad SM, Meyer C, et al. The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs. Nat Commun. 2017,8:16056. doi: 10.1038/ncomms16056
    Read this paper
  • Juszkiewicz S, Hegde RS. Initiation of Quality Control during Poly(A) Translation Requires Site-Specific Ribosome Ubiquitination. Mol Cell. 2017,65(4):743-750.e4. doi: 10.1016/j.molcel.2016.11.039
    Read this paper