Zotizalkib [2648641-36-3]

MedChem Express

Zotizalkib [2648641-36-3]

10

2648641-36-3

Research Use Only

98.02

C21H20F3N5O3

447.41

Zotizalkib (TPX-0131) is a potent, selective, CNS-penetrant and orally active inhibitor of wild-type ALK (IC50 of 1.4 nM) and ALK-resistant mutation, e.g. G1202R (IC50 of 0.3 nM), L1196M (IC50 of 0.3 nM). Zotizalkib has strong antitumor activities[1].

FC([C@H]1N2C3=NC4=C(C(NC(C)(COC5=CC=C(F)C=C5C2)C)=O)C=NN4C=C3OC1)F

-20°C,2°C to 8°C

12352200