ZW-1226

MedChem Express

ZW-1226

9

Research Use Only

98.13

C25H16N4O3

420.42

ZW-1226 is a selective inhibitor of MRP1, reducing the uptake activity of MRP1 vesicles by 65 % at 5 microM. ZW-1226 shows inhibition of MRP1 in a GSH dependent way and good selectivity for MRP1 over other major ABC transporters, including P-gp, BCRP, MRP2 and MRP3[1].

O=C(N=C1C2=CC3=C(C=C(C#N)C=C3)N1C4=CC=C(OCC5=CC=CC=C5)C=C4)NC2=O

RT

12352200