ZX-29

MedChem Express

ZX-29 [2254805-62-2]

5

2254805-62-2

Research Use Only

99.52

C23H28ClN7O3S

518.03

ZX-29 is a potent and selective ALK inhibitor with an IC 50 of 2.1 nM, 1.3 nM and 3.9 nM for ALK , ALK L1196M and ALK G1202R mutations, respectively. ZX-29 is inactive against EGFR. ZX-29 induces apoptosis by inducing endoplasmic reticulum (ER) stress and overcomes cell resistance caused by an ALK mutation. ZX-29 also induces protective autophagy and has antitumor effect [1] .

CS(=O)(NC1=CC=CC=C1NC2=NC(NC3=CC=C(N4CCN(C)CC4)C=C3OC)=NC=C2Cl)=O

2°C to 8°C

12352200