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ZX-29 [2254805-62-2]

ZX-29 [2254805-62-2]

T13416
TargetMol Chemicals
CAS Number2254805-62-2
DownloadMSDS
Product group Chemicals
Estimated Purity98.32%
Molecular Weight518.03
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    ZX-29 [2254805-62-2]
  • Delivery Days Customer
    4
  • CAS Number
    2254805-62-2
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    ZX-29
  • Estimated Purity
    98.32%
  • Molecular Formula
    C23H28ClN7O3S
  • Molecular Weight
    518.03
  • Scientific Description
    ZX-29 is a potent and selective inhibitor of ALK with IC50 values of 2.1 nM, 1.3 nM, and 3.9 nM for ALK, ALK [L1196M], and ALK [G1202R] mutations, respectively. It also induces protective autophagy and exhibits antitumor effects.
  • Shelf life instruction
    3 years
  • SMILES
    COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2NS(C)(=O)=O)n1)N1CCN(C)CC1
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • ZX-29, a novel ALK inhibitor, induces apoptosis via ER stress in ALK rearrangement NSCLC cells and overcomes cell resistance caused by an ALK mutation. Gou W et al., 2020 Jul, Biochim Biophys Acta Mol Cell Res
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