1400W (Dihydrochloride)

MedChem Express

1400W (Dihydrochloride) [214358-33-5]

10

214358-33-5

Research Use Only

99.94

C10H17Cl2N3

250.17

1400W dihydrochloride is the dihydrochloride form of 1400W (HY-18730). 1400W is a slow, tight binding, and highly selective inducible nitric-oxide synthase ( iNOS ) inhibitor, with a K d value ≤ 7 nM. 1400W inhibits iNOS induction in microglial cells, and reduces generation of NO, thereby mitigating oxidative stress and neuronal cell apoptosis in the rat cerebral cortex, and improving the spatial memory dysfunction caused by acute hypobaric hypoxia-reoxygenation [1] [2] .

CC(NCC1=CC=CC(CN)=C1)=N.[H]Cl.[H]Cl

2°C to 8°C

12352200