17-trifluoromethylphenyl trinor Prostaglandin F2alpha [221246-34-0]

MedChem Express

17-trifluoromethylphenyl trinor Prostaglandin F2alpha [221246-34-0]

5

221246-34-0

Research Use Only

C24H31F3O5

456.50

A number of 17-phenyl trinor prostaglandin F2alpha (17-phenyl trinor PGF2alpha) derivatives have been approved for glaucoma. Of these, the unsubstituted or meta-substituted aromatic derivatives are the most potent FP receptor agonists.4 17-trifluoromethylphenyl trinor PGF2alpha bears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl trinor PGF2alpha would act very much like the free acid of travoprost. 17-phenyl trinor PGF2alpha is a potent luteolytic, with a potency equal to or greater than fluprostenol and cloprostenol.

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12352200