3-Hydroxy Midostaurin

Biorbyt

3-Hydroxy Midostaurin

10

179237-49-1

Research Use Only

98.00%

C35H30N4O5

586.648

3-Hydroxy Midostaurin (CGP 52421), a PKC412 metabolite, inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50 values of approximately 132 nM in culture medium and 9.8 microM in plasma. Although less selective, it shows greater cytotoxicity compared to PKC412[1].

CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4C(O)NC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1

-20°C

12352200