3MB-PP1

MedChem Express

3MB-PP1 [956025-83-5]

10

956025-83-5

Research Use Only

99.66

C17H21N5

295.38

3MB-PP1, a bulky purine analog, is a Polo-like kinase 1 ( Plk1 ) inhibitor. 3MB-PP1 blocks mitotic progression and cell division arise through target Plk1 in in cells expressing analog-sensitive Plk1 alleles. 3MB-PP1 specifically inhibits the activity of analog-sensitive Ssn3 ( Cdk8 ). 3MB-PP1 inhibits Leu93 Mutant Zipper-interacting protein kinase ( Leu93-ZIPK ; IC 50 =2 microM). 3MB-PP1 can be used for the research of hypha formation of Candida albicans and cell division [1] [2] [3] .

NC1=C2C(N(C(C)(C)C)N=C2CC3=CC=CC(C)=C3)=NC=N1

-20°C,2°C to 8°C

12352200