3MB-PP1
M49490
CAS Number956025-83-5
Product group Chemicals
Molecular Weight295.38
Overview
- SupplierAbMole BioScience
- Product Name3MB-PP1
- Delivery Days Customer9
- CAS Number956025-83-5
- Category SupplierChemical
- CertificationResearch Use Only
- Molecular FormulaC17H21N5
- Molecular Weight295.38
- Scientific Description3MB-PP1 is a bulky purine analog and inhibitor of Polo-like kinase 1 (Plk1) that blocks mitotic progression and cytokinesis by targeting Plk1 in cells expressing the analog-sensitive Plk1 allele. 3MB-PP1 also specifically inhibits the activity of Leu93 mutant Zipper-interacting Ssn3 (Cdk8). 3MB-PP1 inhibits the activity of Leu93 mutant Zipper-interacting Ssn3 (Cdk8). In addition, 3MB-PP1 specifically inhibits the activity of analog-sensitive Ssn3 (Cdk8). 3MB-PP1 inhibits the Leu93 mutant Zipper-interacting protein kinase (Leu93-ZIPK; IC50=2 uM). 3MB-PP1 can be used in the mycelium of Candida albicans. 3MB-PP1 can be used in studies related to mycelium formation and cell division in Candida albicans.
- UNSPSC12352200