(3S,4S)-PF-06459988

MedChem Express

(3S,4S)-PF-06459988 [1858291-14-1]

10

1858291-14-1

Research Use Only

99.85

C19H22ClN7O3

431.88

(3S, 4S)-PF-06459988 is the S enantiomer of PF-06459988 with less active. PF-06459988 is a potent irreversible inhibitor of T790M mutant epidermal growth factor receptor ( EGFR ). PF-06459988 has excellent selectivity against EGFR wild-type while possessing a minimally reactive electrophile that reduces the propensity of off-target labeling [1] .

C=CC(N1C[C@@H](COC2=C3C(NC=C3Cl)=NC(NC4=CN(C)N=C4)=N2)[C@H](OC)C1)=O

-20°C,2°C to 8°C

12352200