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GTX100329 WB Image
GTX100329 WB Image
GTX100329 WB Image

5-HT2C receptor antibody

Research Use Only
GTX100329
GeneTex
Product group Antibodies
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    GeneTex
  • Product Name
    5-HT2C receptor antibody
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Concentration
    0.68 mg/ml
  • Isotype
    IgG
  • Scientific Description
    Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims. [provided by RefSeq]
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • Melatonin pretreatment alleviates the long-term synaptic toxicity and dysmyelination induced by neonatal Sevoflurane exposure via MT1 receptor-mediated Wnt signaling modulation. Liang L et al., 2021 Dec, J Pineal Res
    Read more
  • Thymosin beta4 reverses phenotypic polarization of glial cells and cognitive impairment via negative regulation of NF-kappaB signaling axis in APP/PS1 mice. Wang M et al., 2021 Jun 28, J Neuroinflammation
    Read more