Western blot of rat hippocampal lysate showing phospho-specific immunolabeling of the ~80k doublet of 5-LO phosphorylated at Ser 523 using 5-Lipoxygenase (phospho Ser523) antibody (GTX82744).
Western blot of rat hippocampal lysate showing phospho-specific immunolabeling of the ~80k doublet of 5-LO phosphorylated at Ser 523 using 5-Lipoxygenase (phospho Ser523) antibody (GTX82744).
5-Lipoxygenase (phospho Ser523) antibody
GTX82744
Overview
- SupplierGeneTex
- Product Name5-Lipoxygenase (phospho Ser523) antibody
- Delivery Days Customer9
- Application Supplier NoteOptimal working dilutions should be determined experimentally by the end user.
- ApplicationsWestern Blot
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID240
- Target nameALOX5
- Target descriptionarachidonate 5-lipoxygenase
- Target synonyms5-LO; 5-LOX; 5LPG; arachidonic acid 5-lipoxygenase; leukotriene A4 synthase; LOG5; LOX-5; polyunsaturated fatty acid 5-lipoxygenase
- HostRabbit
- IsotypeIgG
- Protein IDP09917
- Protein NameArachidonate 5-lipoxygenase
- Scientific DescriptionThis gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
- ReactivityHuman, Rat
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203