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5-Vinyl-2-deoxyuridine (5-VdU) [55520-67-7]

ORB532301
Biorbyt
CAS Number55520-67-7
Product group Chemicals
Estimated Purity≥98%
Molecular WeightTheoretical MW: 254.24 g/mol; Detected MW: 254.09 g/mol
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Overview

  • Supplier
    Biorbyt
  • Product Name
    5-Vinyl-2-deoxyuridine (5-VdU) [55520-67-7]
  • Delivery Days Customer
    16
  • Application Supplier Note
    DNA synthesis monitoring. Spectroscopic Propertie: lambdamax 292 nm, epsilon 9.2 L mmol-1 cm-1, (Methanol).
  • CAS Number
    55520-67-7
  • Certification
    Research Use Only
  • Estimated Purity
    ≥98%
  • Molecular Weight
    Theoretical MW: 254.24 g/mol; Detected MW: 254.09 g/mol
  • Scientific Description
    5-VdU (5-Vinyl-2-deoxyuridine) can be used as a replacement for BrdU (5-Bromo-2-deoxyuridine) or the copper-catalyst requiring 5-EdU (5-Ethynyl-2-deoxyuridine) to measure de novo DNA synthesis during the S-phase of the cell cycle. 5-VdU is cell permeable and incorporates into replicating DNA instead of its natural analog thymidine. The resulting vinyl-functionalized DNA can subsequently be detected via Cu(I)-free Alkene-Tetrazine Ligation that offers the choice to introduce a Biotin group (via Tetrazines of Biotin) for subsequent purification tasks or a fluorescent group (via Tetrazines of fluorescent dyes) for subsequent microscopic imaging.
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

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