ProductsBack/LRP1 antibody [8G1] (FITC)

LRP1 antibody [8G1] (FITC)

Name: LRP1 antibody [8G1] (FITC)
SKU: GTX79841_G10
Availability: BackOrder

GTX79841

ApplicationsDot Blot, Electron Microscopy, Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin, Neutralisation/Blocking

Product group Antibodies

ReactivityHuman

TargetLRP1

Overview

Supplier
GeneTex
Product Name
LRP1 antibody [8G1] (FITC)
Delivery Days Customer
9
Applications
Dot Blot, Electron Microscopy, Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin, Neutralisation/Blocking
Certification
Research Use Only
Clonality
Monoclonal
Clone ID
8G1
Concentration
5 mg/ml
Conjugate
FITC
Gene ID4035
Target name
LRP1
Target description
LDL receptor related protein 1
Target synonyms
A2MR, APOER, APR, CD91, DDH3, IGFBP-3R, IGFBP3R, IGFBP3R1, KPA, LRP, LRP1A, TGFBR5, prolow-density lipoprotein receptor-related protein 1, TbetaR-V/LRP-1/IGFBP-3 receptor, alpha-2-macroglobulin receptor, apolipoprotein E receptor, low density lipoprotein receptor-related protein 1, type V tgf-beta receptor
Host
Mouse
Isotype
IgG1
Protein IDQ07954
Protein Name
Prolow-density lipoprotein receptor-related protein 1
Scientific Description
This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimers disease patients. [provided by RefSeq, Oct 2015]
Reactivity
Human
Storage Instruction
-20°C,2°C to 8°C
UNSPSC
12352203

References

Sivasoorian SS, Urade R, Chiu CC, et al. Neuropeptide-Functionalized Gold Nanorod Enhanced Cellular Uptake and Improved In Vitro Photothermal Killing in LRP1-Positive Glioma Cells. Pharmaceutics. 2022,14(9). doi: 10.3390/pharmaceutics14091939
Read this paper
Boel NM, Hunter MC, Edkins AL. LRP1 is required for novobiocin-mediated fibronectin turnover. Sci Rep. 2018,8(1):11438. doi: 10.1038/s41598-018-29531-2
Read this paper
Leone P, Berardi S, Frassanito MA, et al. Dendritic cells accumulate in the bone marrow of myeloma patients where they protect tumor plasma cells from CD8+ T-cell killing. Blood. 2015,126(12):1443-51. doi: 10.1182/blood-2015-01-623975
Read this paper

Datasheet

Download Datasheet

FAQ

Go to our frequently asked questions

LRP1 antibody [8G1] (FITC)

Large volume orders?

Overview

References

Datasheet

FAQ

Related products