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ProductsBack/LRP1 antibody [8G1] (FITC)

LRP1 antibody [8G1] (FITC)

GTX79841
GeneTex
ApplicationsDot Blot, Electron Microscopy, Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin, Neutralisation/Blocking
DownloadDatasheet
Product group Antibodies
ReactivityHuman
TargetLRP1
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Overview

  • Supplier
    GeneTex
  • Product Name
    515 kDa LRP antibody [8G1] (FITC)
  • Delivery Days Customer
    9
  • Antibody Specificity
    Recognises the 515kDa alpha chain of Low Density LRP/alpha-2-macroglobulin receptor.
  • Applications
    Dot Blot, Electron Microscopy, Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin, Neutralisation/Blocking
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    8G1
  • Concentration
    5 mg/ml
  • Conjugate
    FITC
  • Gene ID4035
  • Target name
    LRP1
  • Target description
    LDL receptor related protein 1
  • Target synonyms
    A2MR; alpha-2-macroglobulin receptor; APOER; apolipoprotein E receptor; APR; CD91; IGFBP3R; IGFBP-3R; IGFBP3R1; KPA; low density lipoprotein receptor-related protein 1; LRP; LRP1A; prolow-density lipoprotein receptor-related protein 1; TbetaR-V/LRP-1/IGFBP-3 receptor; TGFBR5; type V tgf-beta receptor
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDQ07954
  • Protein Name
    Prolow-density lipoprotein receptor-related protein 1
  • Scientific Description
    This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimers disease patients. [provided by RefSeq, Oct 2015]
  • Reactivity
    Human
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Neuropeptide-Functionalized Gold Nanorod Enhanced Cellular Uptake and Improved In Vitro Photothermal Killing in LRP1-Positive Glioma Cells.
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  • LRP1 is required for novobiocin-mediated fibronectin turnover. Boel NM et al., 2018 Jul 30, Sci Rep
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  • Dendritic cells accumulate in the bone marrow of myeloma patients where they protect tumor plasma cells from CD8+ T-cell killing. Leone P et al., 2015 Sep 17, Blood
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